Search results for " oncolytic virus"
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Case Study: Oncolytic Adenovirus Production
Oncolytic viruses constitute a promising therapeutic approach for treatment of cancer. These viruses selectively replicate in tumor cells and effectively kill these cells without harming normal cell…
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Case Study: Process for Production of Oncolytic Adenovirus
The promising results from clinical studies on the use of viral vectors to address important medical needs have spurred interest in developing scalable and cost-efficient manufacturing processes. Here…
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Scalable Viral Vector Manufacturing
The interest for robust and scalable viral vector manufacturing is rapidly increasing, with the recent developments of both cell and gene therapy and oncolytic virus-based therapies. As cost pressur…
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Maximum Output Starts with Optimized Upstream Processing
In the meantime, companies developing new biologics, and in particular vaccines, oncolytic viruses, and gene therapies based on viral vectors, need to identify and access manufacturing capacity as ear…
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Manufacturing of Viral Vectors
Viruses are infectious agents that can only replicate inside of living cells. This trait is used by molecular biologists for the delivery of genetic materials into cells. Viral vectors are also explor…
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Emerging Therapies Test Existing Bioanalytical Methods
Drug developers must understand the complex bioanalytical assays for cell- and gene-therapy drug development programs and ensure that partners have the specialized expertise needed for complex thera…
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Scaling Up Novel Therapies
“Many processes rely on the culture of adherent cells for producing a range of biological molecules, including viral vaccines, viral vectors for gene therapy, and oncolytic viruses. Producing these th…
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Developing an Efficient Adenovirus Downstream Purification Process
Adenovirus is also explored as a potential viral vector for gene therapy and as an oncolytic virus. This application note describes the development of downstream chromatography steps for purification …
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Achieving Efficient Adenovirus Upstream Production
Adenovirus has also been explored as a viral vector for gene therapy and as an oncolytic virus. This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor …